We offer metabolic monitoring systems for measuring your cell culture’s key parameters in-situ and in real-time. Get real time information on Glucose, Lactate, pH and Ammonium. CITSens Bio or CITSens MeMo the single-use in-situ sensors for disposable bioreactors and small scale reaction vessels such as T- or shake flasks.

Download Product Catalog for more information

CITSens Bio

 

.CITSens Bio, in-situ measurement of glucose and lactate

CITSens MeMo

 

CITSens MeMo, in-situ sensors for glucose, lactate, pH and Ammonia

Field of use
  • Mammalian Cell Cultures
  • Microbial Fermentation
  • Blood
  • Mammalian Cell Cultures
  • Microbial Fermentation
  • Blood
Amperometric Sensortypes:
* Combinable Sensors (2 per Beamer)
  • Glucose
  • Lactate
  • Glutamate
  • *Glucose
  • *Lactate
  • *Glutamate
Potentiometric Sensortypes:
* Combinable Sensors (2 per Beamer)

n.a.

pH*
Ammonium*

Reactor Types served
  • PG13.5 Thread (Bioreactor)
  • T-Flasks
  • Shake Flasks
  • Roller Flasks
  • Spinner Flasks
  • Hyperstacks
  • Customized Solutions
  • PG13.5 Thread (Bioreactor)
  • T-Flasks
  • Shake Flasks
  • Roller Flasks
  • Spinner Flasks
  • Hyperstacks
  • Customized Solutions
Available Sensor-shapes
  • PG13.5
  • Cap-Sensor
  • Polymer-coated Sensor
  • PG13.5
  • Cap-Sensor
  • Polymer-coated Sensor
Biosafety grade of Sensor housings

USP Class VI

USP Class VI

Sterilization method

γ-Irradiation

 γ-Irradiation
Minimal working volume

5 ml

5 ml

Temperature Range

20 – 40°C

 20 – 40°C
pH Range
*
pH Shifts during process may lead to deviations in sensor signal

4 – 8 *

4 – 8 *

CITSens Bio & MeMo

Are tailored to continuously analyzing parameters of your interest such as Glucose, Lactate, Glutamate, Ammonium, and pH.The value of using CITSens products is given by:

  • increased yield of product

  • cost reduction

  • reduced manual labor

  • decreased contamination risks

  • detailed and reliable data in real time continuous and disturbance free measurements

  • remote monitoring (data storage, processing and quality control)

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For more information download product catalog

COMPOSITION AND IMPLEMENTATION OF CITSens BIO

CITSens Bio sensors are based on screen printed electrodes which are coated with an immobilized enzyme. The sensor is built into the respective original cap or finished as a PEEK PG13.5 sensor, double packaged and subsequently sterilized by gamma-irradiation.

CITSens Bio disposable and PG13.5 probe
For implementation of the system, the CITSens Bio sensor is connected to the radio transmitter and put into the cell culture. Data measured are transmitted to the ZOMOFI radio receiver and transferred to the PC by means of LAN.

FROM R&D TO PRODUCTION

Continuous and disturbance-free measuring of key metabolic parameters is critical for cell biologists. Cell growth and metabolic activity can be measured instantaneously and such derived data can be used to trigger bioprocess control actions.

 

CITSens Bio glucose and lactate sensor in T-Flask

It is not only the sophisticated labs of biopharmaceutical companies who benefit from the features offered by CITSens Bio but also the many investigators in the different fields of basic cell biology research. Frequent manual interventions for sample taking or optical examination harm cell cultures and disturb their growth. Negative aspects of disturbing growing cell cultures are:

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  • lower cell density resulting in lower product yield

  • metabolic stress and gene expression due to environmental change (carbon dioxide, temperature, pH Shift, seize of agitation)

  • no information on their actual metabolic state by optical inspection

  • risk of contamination

DISTURBANCE-FREE MONITORING

Using CITSens Bio (combining the power of electrochemistry and radio transmission) cell biologists in R&D and production continuously control the growth and metabolism of active cells in real time. With CITSens Bio the optimal time point for interventions such as harvest or optical control are ensured. Cases of contamination are registered at the earliest time possible.

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CONTACT

C-CIT Sensors AG
Headquarter Binningen

Einsiedlerstrasse 34
CH-8820 Waedenswil
Switzerland

Call +41 43 477 85 55